Potential sources of carcinogenic heterocyclic amines in Chinese mutton shashlik
نویسندگان
چکیده
منابع مشابه
Influence of amino acids on the formation of mutagenic/carcinogenic heterocyclic amines in a model system.
Mixtures of creatinine, glucose and various single amino acids were heated at 180 degrees C for 10 min in an aqueous model system. The heated mixtures all showed mutagenic activity, ranging from 80 to 2400 TA98 revertant colonies/mumol creatinine with metabolic activation. Testing of HPLC fractions for mutagenic activity showed each mixture to contain several mutagenic components, some of which...
متن کاملFormation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat.
A group of heterocyclic amines that are mutagens and rodent carcinogens form when meat is cooked to medium and well-done states. The precursors of these compounds are natural meat components: creatinine, amino acids, and sugars. Defined model systems of dry-heated precursors mimic the amounts and proportions of heterocyclic amines found in meat. Results from model systems and cooking experiment...
متن کامل[Present and future cancer risk assessment of carcinogenic heterocyclic amines in humans].
Heterocyclic amines are formed during high temperature cooking of foods such as meat and fish. Although heterocyclic amines are known mutagens and some of them are shown to be carcinogenic to experimental animals, the carcinogenic potential of heterocyclic amines in humans has yet to be established. The most important criteria in determining the relationship between heterocyclic amines and huma...
متن کاملHuman exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals.
Heterocyclic amines (HCAs) are mutagens/carcinogens to which humans are exposed on almost a daily basis. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) is the most abundant of the various carcinogenic HCAs (present at a level of 0.56 to 69.2 ng/g of cooked meat or fish), with 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MelQx) following it at 0.64 to 6.44 ng/g. HCAs have been found in...
متن کاملMetabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes.
The N-hydroxylation of carcinogenic arylamines represents an initial step in their metabolic activation. Animal studies have shown that this reaction is catalyzed by the cytochrome P450 (P450) enzymes P450 1A1 and P450 1A2. In this study, utilizing enzymes expressed in Escherichia coli (and purified) or in human B-lymphoblastoid cells, the catalytic activities of recombinant human P450 1A1, P45...
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ژورنال
عنوان ژورنال: Food Chemistry
سال: 2010
ISSN: 0308-8146
DOI: 10.1016/j.foodchem.2010.05.019